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Product Name: Pharmaceutical Raw Material Diclofenac Sodium CAS: 15307-79-6 Model NO.: USP/BP Volatile: Not Volatile State: Solid Type: Analysis reagent Grade Standard: Medicine Grade Certification: GMP Function: Antibiotic and Antimicrobial Agents, Antipyretic Analgesic and Non-Steroidal Anti-Inflammatory Analgesic appearance: White Crystalline Powder Assay: 99.8% Shelf Life: 3 Years Trademark: SINOAH Transport Package: 25kg/Drum Specification: USP/EP Origin: China HS Code: 3003101200 Product Description Diclofenac sodiumProduct DescriptionDescription ofDiclofenac SodiumDiclofenac Sodium is the salt form of diclofenac, an active metabolite of the NSAID aceclofenac (sc-217557). Hydrolysis ofaceclofenac, an inhibitor of interleukin-1B-induced prostaglandin E2 production with no inhibitory activity against Cox(cyclooxygenase), generates diclofenac, an inhibitor of both Cox-1 and Cox-2. Oxidation of diclofenac produces the metabolite 4'-hydroxy diclofenac (sc-202423) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing antiinflammatory and analgesic effects. Diclofenac is alsoshown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insolubleamyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9.Specification ofDiclofenac SodiumCharacteristicsWhite crystalline powderSolubility:Sparingly soluble in water, freely soluble in methanol, ethanol(96%);slightly soluble in acetone; practically insoluble in ether.,Melting point275-277Related Substances:Single impurity max 0.2%total impurity max 0.5%Heavy metal:Max 10ppmLoss on dryingMax 0.5%Assay:99.0-101.0%
