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Product Name: High Quality 99% Pharmaceutical Intermediates Lifitegrast CAS No. 1025967-78-5 with Competitive Price Model NO.: vanz2020 Purity: >99% State: White Power Suitable for: Adult Certification: ISO 9001, USP Customized: Non-Customized Powder: Yes Trademark: vanz Transport Package: Bag Origin: China HS Code: 2942000000 Product Description Item NameLifitegrastCAS NO.1025967-78-5Molecular FormulaC29H24Cl2N2O7SApplicationXiidra (Lifitegrast Eye drops)ApparenceWhite powderPurity99%AdvantageOEM;ODMCertificateGMP/ISO9001PaymentTrade Assurance; L/C; T/T; Western UnionMolecular structureDescription:Increasing the ability of the eye to produce tears is a substitute for artificial tears Lifitegrast is a FDA approved drug for the treatment of keratoconjunctivitis sicca (dry eye syndrome).It is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design process. The ophthalmic solution was approved in July, 2016 under the trade name Xiidra. It has shown to protect the corneal surface and alleviate the symptoms of dry eye syndrome with fast onset of action and well tolerated profile in both local and systemic setting.Application:Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.Absorption:The mean peak plasma concentration (Cmax) of 1.70ng/mL was reached within 15 minutes of application. Quantifiable trough plasma concentrations ranged from 0.55 ng/mL to 3.74 ng/mL[6]. Observations show limited systemic exposure that produces significant clinical outcomes.Wuhan Vanz Pharm Inc., which is specialized in custom synthesis and R&D, is located in Wuhan, China. our main products are indacaterol, carmoterol etc. We have established long-term cooperation with Shanghai Institute of Organic Chemistry, WuhanUniversity etc. As a special team in organic chemistry and medicinal chemistry, we support the technology of R&D on new product.We have strong advantages on the process research and product R&D, pay attention to researching and developing new technologywhich is self-owned intellectual property right. We are special at developing Drug for the respiratory, antidepressant, antivirus.We have completed R&D of more than 20 APIs and intermediates after the company founded.R&DOur R&D center covers an area of 1000 square meters, with four synthesis labs, one scale-up pilot labs and one analytical lab. Thelab is equipped with complete laboratory facilities and equipment. We have a professional research team of highly qualified andexperienced chemists. most of our R&D team are Master and higher. With their effort, we quickly transfer the science fruit intoproduction. Our manufacturing site is located in Wuhan which is equipped with 100L~5000L reactors; we can offer one-stop services from R&D to commercial production. (Normal reaction/ High-pressure reaction/ Catalytic reaction/ Low-Temperature reaction)Q1:Are you amanufacturer?A:Yes, We manufacture bulk products in our factory located in Jiayu, Hubei, and produce small quantity andcustomer synthesis products in our lab located in Wuhan.Q2:Do you have stock?A:We understand most customers prefer stock, so we'll try to keep stock for most products.However, for some rare products, we won't keep stock and it needs time to synthesize.Q3:What certificates and documents do you offer?A:Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.Q4:Why should Ichoose you?A:Powerful technical support-come from our highly skilled &fully experienced staff, working in chemical industry for over 5years, in average.Strict quality control-comes form our sophisticated management system.Professional and warm sales team-since we believe we can only win via our hard workin acompetitive world Quick response and excellent presale and after sale service-since we believeour customers deserve all the best service.Q5:How should Ipay?A:We accept all kinds of payment ways.Such as T/T, West union, MoneyGram,L/C.
