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Product Name: 99% CAS 15307-79-6 Diclofenac Sodium Model NO.: 15307-79-6 Purity: >98% State: Solid Suitable for: Elderly Certification: GMP Customized: Customized Powder: Yes Trademark: yanxi Transport Package: Bag Specification: 25kg Origin: China HS Code: 29211190 Product Description 99% CAS 15307-79-6 Diclofenac Sodium detailsDescription ofDiclofenac SodiumDiclofenac Sodium is the salt form of diclofenac, an active metabolite of the NSAID aceclofenac (sc-217557). Hydrolysis ofaceclofenac, an inhibitor of interleukin-1B-induced prostaglandin E2 production with no inhibitory activity against Cox(cyclooxygenase), generates diclofenac, an inhibitor of both Cox-1 and Cox-2. Oxidation of diclofenac produces the metabolite 4'-hydroxy diclofenac (sc-202423) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing antiinflammatory and analgesic effects. Diclofenac is alsoshown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insolubleamyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9.Specification ofDiclofenac SodiumCharacteristicsWhite crystalline powderSolubility:Sparingly soluble in water, freely soluble in methanol, ethanol(96%);slightly soluble in acetone; practically insoluble in ether.,Melting point275-277Related Substances:Single impurity max 0.2%total impurity max 0.5%Heavy metal:Max 10ppmLoss on dryingMax 0.5%
